J Genomics 2018; 6:103-112. doi:10.7150/jgen.20581
Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma
1. Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India-211004.
2. Center of Bioinformatics, University of Allahabad, India-211002.
*All authors contributed equally.
Murugesan SN, Yadav BS, Maurya PK, Chaudhary A, Singh S, Mani A. Expression and network analysis of YBX1 interactors for identification of new drug targets in lung adenocarcinoma. J Genomics 2018; 6:103-112. doi:10.7150/jgen.20581. Available from http://www.jgenomics.com/v06p0103.htm
Y-Box Binding protein 1 (YBX-1) is known to be involved in various types of cancers. It's interactors also play major role in various cellular functions. Present work aimed to study the expression profile of the YBX-1 interactors during lung adenocarcinoma (LUAD). The differential expression analysis involved 57 genes from 95 lung adenocarcinoma samples, construction of gene network and topology analysis. A Total of 43 genes were found to be differentially expressed from which 17 genes were found to be down regulated and 26 genes were up-regulated. We observed that Polyadenylate-binding protein 1 (PABPC1), a protein involved in YBX1 translation, is highly correlated with YBX1. The interaction network analysis for a differentially expressed non-coding RNA Growth Arrest Specific 5 (GAS5) suggests that two proteins namely, Growth Arrest Specific 2 (GAS2) and Peripheral myelin protein 22 (PMP22) are potentially involved in LUAD progression. The network analysis and differential expression suggests that Collagen type 1 alpha 2 (COL1A2) can be potential biomarker and target for LUAD.
Keywords: YBX1, regulatory network, lung adenocarcinoma, RNA-Seq.