J Genomics 2021; 9:26-37. doi:10.7150/jgen.53019

Research Paper

Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity

Tawanda Elias Maguvu, Adegboyega Oyedele Oladipo, Cornelius Carlos Bezuidenhout

Unit for Environmental Sciences and Management: Microbiology, North-West University, Potchefstroom, South Africa. Private Bag X6001, Potchefstroom, 2520, South Africa

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Citation:
Maguvu TE, Oladipo AO, Bezuidenhout CC. Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity. J Genomics 2021; 9:26-37. doi:10.7150/jgen.53019. Available from https://www.jgenomics.com/v09p0026.htm

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Abstract

Here, we report high-quality annotated draft genomes of eight coagulase-negative staphylococci (CoNS) isolates obtained from South Africa and Nigeria. We explored the prevalence of antibiotic resistance and virulence genes, their association with mobile genetic elements. The pan-genomic analysis highlighted the environmentally driven heterogeneity of the isolates. Isolates from Nigeria had at least one gene for cadmium resistance/tolerance, these genes were not detected in isolates from South Africa. In contrast, isolates from South Africa had a tetM gene, which was not detected among the isolates from Nigeria. The observed genomic heterogeneity correlates with anthropogenic activities in the area where the isolates were collected. Moreover, the isolates used in this study possess an open pan-genome, which could easily explain the environmentally driven heterogeneity.

Keywords: Antibiotic resistance, Coagulase-negative staphylococci (CoNS), environmentally driven heterogeneity, Pan-genome analysis.