J Genomics 2013; 1:22-28. doi:10.7150/jgen.3781
Adipogenic Transcriptome Profiling Using High Throughput Technologies
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
Basu U, Romao JM, Guan LL. Adipogenic Transcriptome Profiling Using High Throughput Technologies. J Genomics 2013; 1:22-28. doi:10.7150/jgen.3781. Available from http://www.jgenomics.com/v01p0022.htm
The recent technological innovations in the area of functional genomics, gene expression/transcriptomic profiling can provide new insights to understand the molecular basis of adipogenesis. The focus of this review is to highlight the recent advances in our understanding of the complex interplay of gene expression events and the regulatory mechanisms of adipogenesis in mouse cell lines, humans and farm animals. All these studies have employed the availability of constantly evolving high throughput 'omics' technologies including microarrays, RNA-Seq, chromatin immunoprecipitation, next generation sequencing, RNAi, miRNA profiling and quantitative PCR arrays.
Keywords: transcriptome, adipogenesis, functional genomics, gene expression