J Genomics 2021; 9:10-19. doi:10.7150/jgen.55545

Review

The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes

Konstantinos Giannopoulos1,2✉, Maria Gazouli3, Klio Chatzistefanou1, Anthi Bakouli4, Marilita M Moschos1

1. First Department of Ophthalmology, Gennimatas General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
2. Department of Ophthalmology, General Hospital of Sitia, Sitia, Greece
3. Department of Basic Medical Sciences, Laboratory of Biology, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
4. Department of Ophthalmology, Elpis General Hospital, Athens, Greece

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Citation:
Giannopoulos K, Gazouli M, Chatzistefanou K, Bakouli A, Moschos MM. The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes. J Genomics 2021; 9:10-19. doi:10.7150/jgen.55545. Available from https://www.jgenomics.com/v09p0010.htm

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Abstract

Central serous chorioretinopathy is characterized by neurosensory detachment of the central retina secondary to fluid leakage through the retinal pigment epithelium. Though it has an incidence of 9,9 per 100.000 in men and 1,7 per 100.000 in women, it is the fourth most common retinal disorder. Central serous chorioretinopathy patients present with blurred vision, central scotoma, metamorphopsia, micropsia and mild color discrimination. It is usually a self-limited disorder with nearly none or minimal visual impairment but in some patients the disease persists and may cause severe visual impairment. Central serous chorioretinopathy pathophysiology is not well understood. Choroid, retinal pigment epithelium and hormonal pathways seem to play important roles in central serous chorioretinopathy pathophysiology. Also, familial cases of the disease indicate that there is a genetic background. The identification of certain disease genes could lead to the development of better diagnostic and therapeutic approaches for central serous chorioretinopathy patients.

Keywords: Central Serous Chorioretinopathy, Diagnosis, Genes, Pathophysiology, Review