J Genomics 2013; 1:45-55. doi:10.7150/jgen.3996
Obesity Gene Atlas in Mammals
1. Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domzale, Slovenia;
2. Centre for Mathematical and Computational Biology, Rothamsted Research, Harpenden, Herts, AL5, 2JQ, UK;
3. Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351, USA.
* Authors contributed equally to the work.
Kunej T, Jevsinek Skok D, Zorc M, Ogrinc A, Michal JJ, Kovac M, Jiang Z. Obesity Gene Atlas in Mammals. J Genomics 2013; 1:45-55. doi:10.7150/jgen.3996. Available from http://www.jgenomics.com/v01p0045.htm
Obesity in humans has increased at an alarming rate over the past two decades and has become one of the leading public health problems worldwide. Studies have revealed a large number of genes/markers that are associated with obesity and/or obesity-related phenotypes, indicating an urgent need to develop a central database for helping the community understand the genetic complexity of obesity. In the present study, we collected a total of 1,736 obesity associated loci and created a freely available obesity database, including 1,515 protein-coding genes and 221 microRNAs (miRNAs) collected from four mammalian species: human, cattle, rat, and mouse. These loci were integrated as orthologs on comparative genomic views in human, cattle, and mouse. The database and genomic views are freely available online at:
Keywords: adipogenesis, fat deposition, integratomics, mammals, microRNA (miRNA), obesity.