Editor-in-Chief:
Brian Oliver, Ph.D., Bethesda, MD
new Journal of Genomics is indexed in PubMed (abstract) and PubMed Central (full text). Congratulation!
The Y chromosomes of Drosophila melanogaster and D. simulans contain only a handful of protein-coding genes, which are related to sperm mobility and reproductive fitness. Despite low or absent protein coding polymorphism, the Drosophila Y chromosome has been associated with natural phenotypic variation, including variation in the expression of hundreds to thousands of genes located on autosomes and on the X chromosome. Polymorphisms present in the large blocks of heterochromatin and consisting of differences in the amounts and kinds of sequences for satellite DNA and transposable elements may be the source of this modulation. ...more
It has long been recognized that men and women exhibit different risks for diverse disorders ranging from metabolic to autoimmune diseases. However, the underlying causes of these disparities remain obscure. Analysis of patients with chromosomal abnormalities, including Turner syndrome (45X) and Klinefelter syndrome (47XXY), has highlighted the importance of X-linked gene dosage as a contributing factor for disease susceptibility. Escape from X-inactivation and X-linked imprinting can result in transcriptional differences between normal men and women as well as in patients with sex chromosome abnormalities. ...more
Frog sex chromosomes offer an ideal system for advancing our understanding of genome evolution and function because of the variety of sex determination systems in the group, the diversity of sex chromosome maturation states, the ease of experimental manipulation during early development. After briefly reviewing sex chromosome biology generally, we focus on what is known about frog sex determination, sex chromosome evolution, and recent, genomics-facilitated advances in the field. ...more
Genetic variation in the genome of a given species is the basis for natural selection and genetic improvement through selective breeding. We applied 29 microsatellites located on 11 linkage groups to study genetic variation in 276 accessions of J. curcas collected from nine locations in five countries in South America, Asia and Africa to initiate a breeding program. To our surprise, we did not detect any genetic diversity at all 29 microsatellites loci. All the 276 accessions were homozygous at all loci and shared the same genotype at each locus, suggesting no microsatellite variation in the genome of Jatropha curcas. This result is quite unusual, and may have profound influence of the breeding strategies and genome study of this species. ...more
The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Psyllidae) is a vector for the causative agents of Huanglongbing, which threatens citrus production worldwide. This study reports and discusses the first D. citri transcriptomes, encompassing the three main life stages of D. citri, egg, nymph and adult. The transcriptomes were annotated using Gene Ontology (GO) and insecticide-related genes within each life stage were identified to aid the development of future D. citri insecticides. Transcriptome assemblies and other sequence data are available for download at the International Asian Citrus Psyllid Genome Consortium website and at NCBI. ...more
Candidate gene (CG) approaches provide a strategy for identification and characterization of major genes underlying complex phenotypes such as production traits and susceptibility to diseases, but the conclusions tend to be inconsistent across individual studies. Meta-analysis approaches can deal with these situations, e.g., by pooling effect-size estimates or combining P values from multiple studies. In this paper, we evaluated the performance of two types of statistical models, parametric and non-parametric, for meta-analysis of CG effects using simulated data. Both models estimated a “central” effect size while taking into account heterogeneity over individual studies. The empirical distribution of study-specific CG effects was multi-modal. ...more
A collection of investigations indicate the importance of adipose tissue stromal/stem cells to vasculogenesis and angiogenesis during adipogenesis. Early in development the stromal-vascular (S-V) elements control and dictate the extent of adipogenesis. For instance, the vasculature and connective tissue collagen matrix develops before overt adipocyte differentiation. Definitive studies of human adipose tissue stem cells (ADSC) provided an understanding of stem cell identity and function. In this regard, a novel vascular stem cell theory proposes that ADSC are a mixed population of vascular stem cells (VSC) with differential potential proportional to the angiogenic potential of the vasculature....more

Journal of Genomics cover

Journal of Genomics is a peer-reviewed journal publishing papers of high quality in all aspects of genomics, proteomics, gene research and application. Types of articles include:

  • Research paper
  • Short research communication
  • Review
  • Letter or correspondence
  • Commentary
  • Database
  • Software

Latest articles:

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Research Paper
Urochordate serpins Are Classified into Six Groups Encoded by Exon-Intron Structures, Microsynteny and Bayesian Phylogenetic Analyses
Abhishek Kumar, Anita Bhandari
J. Genomics 2014; 2: 131-140. doi:10.7150/jgen.9437
[Abstract] [Full text] [PDF]


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Research Paper
Characterization of Distinct Classes of Differential Gene Expression in Osteoblast Cultures from Non-Syndromic Craniosynostosis Bone
Monica L. Rojas-Peña, Rene Olivares-Navarrete, Sharon Hyzy, Dalia Arafat, Zvi Schwartz, Barbara D. Boyan, Joseph Williams, Greg Gibson
J. Genomics 2014; 2: 121-130. doi:10.7150/jgen.8833
[Abstract] [Full text] [PDF]


Short Research Communication
Draft Genome Sequence of the Extremely Halophilic Phototrophic Purple Sulfur Bacterium Halorhodospira halochloris
Kumar Saurabh Singh, Jared Kirksey, Wouter D. Hoff, Ratnakar Deole
J. Genomics 2014; 2: 118-120. doi:10.7150/jgen.9123
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Meiotic Sex Chromosome Inactivation in Drosophila
Maria D. Vibranovski
J. Genomics 2014; 2: 104-117. doi:10.7150/jgen.8178
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
How Do Y-Chromosomes Modulate Genome-Wide Epigenetic States: Genome Folding, Chromatin Sinks, and Gene Expression
Flávio O. Francisco, Bernardo Lemos
J. Genomics 2014; 2: 94-103. doi:10.7150/jgen.8043
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Enly: Improving Draft Genomes through Reads Recycling
Marco Fondi, Valerio Orlandini, Giorgio Corti, Marco Severgnini, Marco Galardini, Alessandro Pietrelli, Fabio Fuligni, Michele Iacono, Ermanno Rizzi, Gianluca De Bellis, Renato Fani
J. Genomics 2014; 2: 89-93. doi:10.7150/jgen.7298
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Chromosome Imbalance as a Driver of Sex Disparity in Disease
Lara K. Abramowitz, Stéphanie Olivier-Van Stichelen, John A. Hanover
J. Genomics 2014; 2: 77-88. doi:10.7150/jgen.8123
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
The Sex Chromosomes of Frogs: Variability and Tolerance Offer Clues to Genome Evolution and Function
Jacob W. Malcom, Randal S. Kudra, John H. Malone
J. Genomics 2014; 2: 68-76. doi:10.7150/jgen.8044
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Short Research Communication
A Novel Dataset for Identifying Sex-Biased Genes in Drosophila
Nicholas W. VanKuren, Maria D. Vibranovski
J. Genomics 2014; 2: 64-67. doi:10.7150/jgen.7955
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Short Research Communication
No Variation at 29 Microsatellites in the Genome of Jatropha curcas
Gen Hua Yue, Loong Chueng Lo, Fei Sun, Su Ying Cao, Cheng Xin Yi, Yan Hong, Wei Bang Sun
J. Genomics 2014; 2: 59-63. doi:10.7150/jgen.7435
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Short Research Communication
Characterization of the Asian Citrus Psyllid Transcriptome
Justin Reese, Matthew K. Christenson, Nan Leng, Surya Saha, Brandi Cantarel, Magdalen Lindeberg, Cecilia Tamborindeguy, Justin MacCarthy, Daniel Weaver, Andrew J. Trease, Steven V. Ready, Vincent M. Davis, Courtney McCormick, Christian Haudenschild, Shunsheng Han, Shannon L. Johnson, Kent S. Shelby, Hong Huang, Blake R. Bextine, Robert G. Shatters, David G. Hall, Paul H. Davis, Wayne B. Hunter
J. Genomics 2014; 2: 54-58. doi:10.7150/jgen.7692
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Renin Gene Polymorphisms in Bangladeshi Hypertensive Population
Rownock Afruza, Laila N Islam, Sajal Banerjee, Md. Mahbub Hassan, Fumiaki Suzuki, AHM Nurun Nabi
J. Genomics 2014; 2: 45-53. doi:10.7150/jgen.5193
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals
Katrin Komolka, Elke Albrecht, Klaus Wimmers, Jennifer J. Michal, Steffen Maak
J. Genomics 2014; 2: 31-44. doi:10.7150/jgen.5260
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Analysis of Diversity and Linkage Disequilibrium Mapping of Agronomic Traits on B-Genome of Wheat
Haixia Yu, Zhiying Deng, Changfen Xiang, Jichun Tian
J. Genomics 2014; 2: 20-30. doi:10.7150/jgen.4089
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Meta-Analysis of Candidate Gene Effects Using Bayesian Parametric and Non-Parametric Approaches
Xiao-Lin Wu, Daniel Gianola, Guilherme J. M. Rosa, Kent A. Weigel
J. Genomics 2014; 2: 1-19. doi:10.7150/jgen.5054
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Review
Stromal Vascular Cells and Adipogenesis: Cells within Adipose Depots Regulate Adipogenesis
Gary J. Hausman, Michael V. Dodson
J. Genomics 2013; 1: 56-66. doi:10.7150/jgen.3813
[Abstract] [Full text] [PDF] [PubMed] [PMC]